Update on diagnosis and monitoring of cystic fibrosis-related diabetes mellitus (CFRD)

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Update on diagnosis and monitoring of cystic fibrosis-related diabetes mellitus (CFRD).

Cystic fibrosis (CF) is the most common recessive autosomal disease among Caucasian. Children with CF have benefitted from advances in medical and nutritional treatments, and this can be gleaned from the improvement in the survival of these patients. The increase in the survival rate brought with it the appearance of co-morbidities related to CF. Nowadays cystic fibrosis-related diabetes (CFRD)...

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Update on cystic fibrosis-related diabetes.

PURPOSE OF REVIEW The aim is to provide a detailed review of recent publications on cystic fibrosis-related diabetes (CFRD) with a particular focus on the interplay between cystic fibrosis (CF) lung disease and diabetes. RECENT FINDINGS CFRD is a form of diabetes that is distinct from type 1 or type 2 diabetes. CFRD remains very common and increases in prevalence with increasing age so that o...

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Cystic Fibrosis-Related Diabetes: Screening and Diagnosis

CFRD — Cystic fibrosis-related diabetes — is the most prevalent extrapulmonary complication of cystic fibrosis and is associated with decline in pulmonary function, poor nutritional status, and greater mortality. Although our general understanding of CFRD has increased, difficult areas remain in its pathophysiology, screening, diagnosis, and management that require further research and developm...

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The use of fructosamine in cystic fibrosis-related diabetes (CFRD) screening.

OBJECTIVE To determine whether serum fructosamine correlates with glycemic control and clinical outcomes in patients being screened for cystic fibrosis-related diabetes (CFRD). METHODS Fructosamine and percent predicted forced expiratory volume in 1s (FEV1) were measured in patients undergoing a 2h oral glucose tolerance test (OGTT) for CFRD screening. Fractional serum fructosamine (FSF) was ...

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Cystic fibrosis related diabetes.

Diabetes is a frequent complication seen in cystic fibrosis patients as they reach adulthood. Cystic fibrosis related diabetes (CFRD) is distinguished as a separate entity with features that include progressive loss of islet beta cell mass and insulin deficiency, as well as insulin resistance. Abnormalities in glucose tolerance may be detectable for many years prior to the development of overt ...

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ژورنال

عنوان ژورنال: Arquivos Brasileiros de Endocrinologia & Metabologia

سال: 2011

ISSN: 0004-2730

DOI: 10.1590/s0004-27302011000800016